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Article

HDAC4 protein regulates HIF1α protein lysine acetylation and cancer cell response to hypoxia.

The Journal of biological chemistry - 4 Nov 2011

Geng Hao, Harvey Chris T, Pittsenbarger Janet, Liu Qiong, Beer Tomasz M, Xue Changhui, Qian David Z

Abstract excerpt

Hypoxia-inducible factor 1 α (HIF1α) is an essential part of the HIF-1 transcriptional complex that regulates angiogenesis, cellular metabolism, and cancer development. In von Hippel-Lindau (VHL)-null kidney cancer cell lines, we reported previously that HIF1α proteins can be acetylated and inhibited by histone deacetylase (HDAC) inhibitors or specific siRNA against HDAC4. To investigate the mechanism and...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Source

Open in PubMed Open full text

Identifiers

PMID: 21917920
DOI: 10.1074/jbc.M111.257055
PMCID: PMC3207467

Genes

HDAC4
VHL
HDAC1
HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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