Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity.

The Journal of biological chemistry - 14 Aug 2009

Sun Xiaojuan, Wei Lei, Chen Qian, Terek Richard M

Abstract excerpt

Chondrosarcoma is a primary bone tumor with a dismal prognosis; most patients with this disease develop fatal pulmonary metastases, suggesting the need for a better systemic treatment. Anti-angiogenesis treatment may be useful, because angiogenesis is critical for both tumor growth and metastasis. Vascular endothelial growth factor (VEGF) is the most potent pro-angiogenic factor and is regulated by pathways...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cartilage
Share to Chondrosarcoma
Share to Core Binding Factor Alpha 1 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Culture Media, Conditioned

Share to Histone Deacetylases

Share to Hypoxia

Share to Neovascularization, Pathologic

Share to Vascular Endothelial Growth Factor A

Source

Open in PubMed Open full text

Identifiers

PMID: 19509297
DOI: 10.1074/jbc.M109.019091
PMCID: PMC2755912

Genes

HDAC4
RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity.PMID 19509297Read ↗

Conditional deletion of HDAC4 from collagen type 2α1-expressing cells increases angiogenesis in vivo.Semantic proximity Read ↗

Histone Deacetylases: Anti-Angiogenic Targets in Cancer TherapySemantic proximity Read ↗

IDH1 Mutation Induces HIF-1α and Confers Angiogenic Properties in Chondrosarcoma JJ012 Cells.Semantic proximity Read ↗

CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expressionSemantic proximity Read ↗

A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progressionSemantic proximity Read ↗

Association of Elevated HIF-2α Levels with Low Beclin 1 Expression and Poor Prognosis in Patients with ChondrosarcomaSemantic proximity Read ↗

Molecular oncogenesis of chondrosarcoma: impact for targeted treatmentSemantic proximity Read ↗

Novel therapeutic approaches in chondrosarcoma.Semantic proximity Read ↗

Molecular Crosstalk Between RUNX2 and HIF-1α in Osteosarcoma: Implications for Angiogenesis, Metastasis, and Therapy ResistanceSemantic proximity Read ↗

New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance.Semantic proximity Read ↗

MicroRNA Regulates Vascular Endothelial Growth Factor Expression in Chondrosarcoma CellsSemantic proximity Read ↗

Decreased expression of the HDAC2 disrupts the SLIT-ROBO signaling pathway and induced angiogenesis in placental endothelial cells in preeclampsiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.