Article

Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells

2023-03-12

Abstract excerpt

<h4>Introduction</h4> Posttranslational modification of proteins by reversible acetylation regulates key biological processes. Histone deacetylases (HDACs) catalyze protein deacetylation and are frequently dysregulated in tumors. This has spurred the development of HDAC inhibitors (HDACi). Such epigenetic drugs modulate protein acetylation, eliminate tumor cells, and are approved for the treatment of blood cancer...

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Literature Corpus work: a4f0d32f-ba45-583f-8a44-92420cf8e97a
DOI: 10.1101/2023.03.09.531973

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