Article

Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors

2021-03-17

Abstract excerpt

<h4>Summary</h4> Angiogenesis is essential for sustained growth of solid tumors. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of angiogenesis and constitutive activation of HIF-1 is frequently observed in human cancers. Thus, understanding mechanisms governing the activation of HIF-1 is critical for successful therapeutic targeting of tumor angiogenesis. Herein, we establish a new regulatory mechanism...

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Literature Corpus work: 0fa0924e-fee4-5a82-be76-e669fd41bb3e
DOI: 10.1101/2021.03.17.435865

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