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HIF-2α expression and metabolic signaling require ACSS2 in clear cell renal cell carcinoma

16 Jun 2024

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is an aggressive cancer driven by VHL loss and aberrant HIF-2α signaling. Identifying means to regulate HIF-2α thus has potential therapeutic benefit. Acetyl-CoA synthetase 2 (ACSS2) converts acetate to acetyl-CoA and is associated with poor patient prognosis in ccRCC. Here we tested the effects of ACSS2 on HIF-2α and cancer cell metabolism and growth in ccRCC models and...

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PMID: 38941296
DOI: 10.1172/jci164249

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