The effect of E1A transfection on MMP-9 expression and metastatic potential.

doi:10.1002/ijc.2910600525

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Article

The effect of E1A transfection on MMP-9 expression and metastatic potential.

International journal of cancer - 3 Mar 1995

Bernhard E J, Hagner B, Wong C, Lubenski I, Muschel R J

Abstract excerpt

The expression of MMP-9 in rat embryo fibroblasts (REF) transformed with Ha-ras or with Ha-ras and v-myc is associated with metastatic behavior. In contrast, REF transformed with Ha-ras and the adenovirus E1A genes (E1A) are tumorigenic, do not release MMP-9 and are rarely metastatic. In this report, we establish that E1A expression results in decreased levels of MMP-9 mRNA in an Ha-ras and v-myc transformed cell...

Topics

Adenovirus E1A Proteins
Animals
Cell Line, Transformed
Cell Transformation, Viral
Clone Cells
Collagenases
Embryo, Mammalian
Enzyme Induction
Female
Fibroblasts
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Viral

Genes, myc

Genes, ras

Lung Neoplasms

Matrix Metalloproteinase 9

Mice

Mice, Nude

Source

Open in PubMed

Identifiers

PMID: 7860147
DOI: 10.1002/ijc.2910600525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7860147-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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