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Article

Metastatic phenotype: growth factor dependence and integrin expression.

Anticancer research - 1 Jan 2000

Perrotti D, Cimino L, Falcioni R, Tibursi G, Gentileschi M P, Sacchi A

Abstract excerpt

Homogeneous subpopulations, which are endowed with low or high metastatic potential, were selected from Lewis lung carcinoma (3LL) in an attempt to correlate metastatic phenotype with specific properties of tumor cells. Since the growth of malignant cells at secondary sites could depend on their ability to respond to microenvironments, the growth factor dependence of 3LL variants has been studied. The ability of...

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PMID: 2285230

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