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Article

Pathways of colorectal carcinogenesis.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Mar 2013

Arends Mark J

Abstract excerpt

This review of the molecular and cellular changes in the different pathways of colorectal carcinogenesis sets out the classic adenoma-carcinoma sequence of the large bowel as a stepwise series of pathologic neoplastic changes associated with accumulation of genetic and epigenetic molecular alterations. The 2 major types of genomic instability found in colorectal cancers are chromosomal instability (CIN) and...

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Source

Identifiers

PMID: 23417071
DOI: 10.1097/PAI.0b013e31827ea79e

Genes

APC
MLH1
MSH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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