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Article

Proven non-carriers in BRCA families have an earlier age of onset of breast cancer.

European journal of cancer (Oxford, England : 1990) - 1 Jun 2013

Vos Janet R, de Bock Geertruida H, Teixeira Natalia, van der Kolk Dorina M, Jansen Liesbeth, Mourits Marian J E, Oosterwijk Jan C

Abstract excerpt

BACKGROUND: Risk estimates for proven non-carriers in BRCA mutation families are inconsistent for breast cancer and lacking for ovarian cancer. We aimed to assess the age-related risks for breast and ovarian cancer for proven non-carriers in these families. METHODS: A consecutive cohort study ascertained 464 proven non-carriers who had a first-degree relative with a pathogenic BRCA mutation. Kaplan-Meier analyses...

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Identifiers

PMID: 23490645
DOI: 10.1016/j.ejca.2013.02.018

Genes

BRCA1

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