Article
Do BRCA1/2 mutation carriers have an earlier onset of natural menopause?
Menopause (New York, N.Y.) - 1 Aug 2016
van Tilborg Theodora C, Broekmans Frank J, Pijpe Anouk, Schrijver Lieske H, Mooij Thea M, Oosterwijk Jan C, Verhoef Senno, Gómez Garcia Encarna B, van Zelst-Stams Wendy A, Adank Muriel A, van Asperen Christi J, van Doorn Helena C, van Os Theo A, Bos Anna M, Rookus Matti A, Ausems Margreet G
Abstract excerpt
OBJECTIVE: It has been hypothesized that BRCA1/2 mutation carriers have an earlier age at natural menopause (ANM), although to date findings are inconclusive. This study assessed the influence of BRCA mutation status on ANM, and aimed to explore the reasons of inconsistency in the literature. METHODS: Cross-sectional assessment from an ongoing nationwide cohort study among members of BRCA1/2 mutated families....
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