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BRCA 1, 2 mutation and earlier menopause: could BRCA 1,2 be used as predictor of menopause?

Minerva obstetrics and gynecology - 1 Apr 2022

Nikolettos Konstantinos, Damaskos Christos, Garmpis Nikolaos, Nikolettos Nikos

Abstract excerpt

INTRODUCTION: Many studies have shown that BRCA mutation is not only related to cancer but also to ovarian aging. Studies in both human and mice oocytes have shown that Double-strand breaks (DSBs) accumulate with age. EVIDENCE ACQUISITION: A review of the literature was completed through the PubMed database aiming to find articles regarding BRCA 1,2 mutation and if they are related to early menopause in order to...

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PMID: 34137566
DOI: 10.23736/S2724-606X.21.04813-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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