Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hereditary susceptibility to breast cancer: significance of age of onset in family history and contribution of BRCA1 and BRCA2.

Disease markers - 1 Oct 1999

Frank T S, Deffenbaugh A M, Hulick M, Gumpper K

Abstract excerpt

OBJECTIVE: To correlate mutations in BRCA1 and BRCA2 with family history of breast cancer in a first-degree relative for women diagnosed with breast cancer before age 45 who do not have a personal or family history of ovarian cancer. METHODS: Family history for women with breast cancer diagnosed before age 45 was provided by ordering physicians via a test requisition form designed for this purpose. Gene analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA2 Protein
Share to DNA, Neoplasm
Share to Genes, BRCA1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasm Proteins

Share to Neoplastic Syndromes, Hereditary

Share to Oncogenes

Share to Ovarian Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 10595259
DOI: 10.1155/1999/291023
PMCID: PMC3851969

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hereditary susceptibility to breast cancer: significance of age of onset in family history and contribution of BRCA1 and BRCA2.PMID 10595259Read ↗

Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer.Semantic proximity Read ↗

Familial risks, early-onset breast cancer, and BRCA1 and BRCA2 germline mutations.Semantic proximity Read ↗

Does the age of breast cancer diagnosis in first-degree relatives impact on the risk of breast cancer in BRCA1 and BRCA2 mutation carriers?Semantic proximity Read ↗

Family History of Breast and Ovarian Cancers and BRCA1 and BRCA2 Mutations in a Population-Based Series of Early-Onset Breast CancerSemantic proximity Read ↗

BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives.Semantic proximity Read ↗

A family history of breast cancer will not predict female early onset breast cancer in a population-based setting.Semantic proximity Read ↗

Ovarian cancer onset across different BRCA mutation types: a view to a more tailored approach for BRCA mutated patients.Semantic proximity Read ↗

Increased cancer risks for relatives of very early-onset breast cancer cases with and without BRCA1 and BRCA2 mutations.Semantic proximity Read ↗

Family history of breast cancer in relation to tumor characteristics and mortality in a population-based study of young women with invasive breast cancer.Semantic proximity Read ↗

Cancer incidence in relatives of a population-based set of cases of early-onset breast cancer with a known BRCA1 and BRCA2 mutation status.Semantic proximity Read ↗

The risk of breast cancer in BRCA1 and BRCA2 mutation carriers without a first-degree relative with breast cancer.Semantic proximity Read ↗

Does family history predict the age at onset of new breast cancers in BRCA1 and BRCA2 mutation-positive families?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.