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Article

Removal of GABA(A) receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations.

PloS one - 1 Jan 2011

Leppä Elli, Linden Anni-Maija, Vekovischeva Olga Y, Swinny Jerome D, Rantanen Ville, Toppila Esko, Höger Harald, Sieghart Werner, Wulff Peer, Wisden William, Korpi Esa R

Abstract excerpt

We investigated the behavioral significance of fast synaptic inhibition by αβγ2-type GABA(A) receptors on parvalbumin (Pv) cells. The GABA(A) receptor γ2 subunit gene was selectively inactivated in Pv-positive neurons by Cre/loxP recombination. The resulting Pv-Δγ2 mice were relatively healthy in the first postnatal weeks; but then as Cre started to be expressed, the mice progressively developed wide-ranging...

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Identifiers

PMID: 21912668
DOI: 10.1371/journal.pone.0024159
PMCID: PMC3166293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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