Article
Rescue of gamma2 subunit-deficient mice by transgenic overexpression of the GABAA receptor gamma2S or gamma2L subunit isoforms.
The European journal of neuroscience - 1 Jul 2000
Baer K, Essrich C, Balsiger S, Wick M J, Harris R A, Fritschy J M, Lüscher B
Abstract excerpt
The gamma2 subunit is an important functional determinant of GABAA receptors and is essential for formation of high-affinity benzodiazepine binding sites and for synaptic clustering of major GABAA receptor subtypes along with gephyrin. There are two splice variants of the gamma2 subunit, gamma2 short (gamma2S) and gamma2 long (gamma2L), the latter carrying in the cytoplasmic domain an additional eight amino acids...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
