Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elongator complex influences telomeric gene silencing and DNA damage response by its role in wobble uridine tRNA modification.

PLoS genetics - 1 Sept 2011

Chen Changchun, Huang Bo, Eliasson Mattias, Rydén Patrik, Byström Anders S

Abstract excerpt

Elongator complex is required for formation of the side chains at position 5 of modified nucleosides 5-carbamoylmethyluridine (ncm⁵U₃₄), 5-methoxycarbonylmethyluridine (mcm⁵U₃₄), and 5-methoxycarbonylmethyl-2-thiouridine (mcm⁵s²U₃₄) at wobble position in tRNA. These modified nucleosides are important for efficient decoding during translation. In a recent publication, Elongator complex was implicated to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Gene Silencing
Share to Proliferating Cell Nuclear Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA, Transfer

Share to RNA, Transfer, Gln

Share to RNA, Transfer, Lys

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

Share to Telomere

Source

Open in PubMed Open full text

Identifiers

PMID: 21912530
DOI: 10.1371/journal.pgen.1002258
PMCID: PMC3164696

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elongator complex influences telomeric gene silencing and DNA damage response by its role in wobble uridine tRNA modification.PMID 21912530Read ↗

An early step in wobble uridine tRNA modification requires the Elongator complex.Semantic proximity Read ↗

Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis.Semantic proximity Read ↗

SSD1 modifies phenotypes of Elongator mutants.Semantic proximity Read ↗

Dual function of the tRNA(m(5)U54)methyltransferase in tRNA maturation.Semantic proximity Read ↗

A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast.Semantic proximity Read ↗

Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication.Semantic proximity Read ↗

Identification of the TRM2 gene encoding the tRNA(m5U54)methyltransferase of Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional conservation of tRNase ZL among Saccharomyces cerevisiae, Schizosaccharomyces pombe and humans.Semantic proximity Read ↗

The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.Semantic proximity Read ↗

MLL Associates with Telomeres and Regulates Telomeric Repeat-Containing RNA TranscriptionSemantic proximity Read ↗

The conserved wobble uridine tRNA thiolase Ctu1 is required to sustain development and differentiationSemantic proximity Read ↗

A 4-base pair core-enclosing helix in telomerase RNA is essential and binds to the TERT catalytic protein subunitSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.