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Article

A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast.

RNA (New York, N.Y.) - 1 Aug 2007

Björk Glenn R, Huang Bo, Persson Olof P, Byström Anders S

Abstract excerpt

Transfer RNAs specific for Gln, Lys, and Glu from all organisms (except Mycoplasma) and organelles have a 2-thiouridine derivative (xm(5)s(2)U) as wobble nucleoside. These tRNAs read the A- and G-ending codons in the split codon boxes His/Gln, Asn/Lys, and Asp/Glu. In eukaryotic cytoplasmic tRNAs the conserved constituent (xm(5)-) in position 5 of uridine is 5-methoxycarbonylmethyl (mcm(5)). A protein (Tuc1p)...

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Identifiers

PMID: 17592039
DOI: 10.1261/rna.558707
PMCID: PMC1924908

Genes

ELP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast.PMID 17592039Read ↗

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