A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast.

doi:10.1261/rna.558707

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Article

A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast.

RNA (New York, N.Y.) - 1 Aug 2007

Björk Glenn R, Huang Bo, Persson Olof P, Byström Anders S

Abstract excerpt

Transfer RNAs specific for Gln, Lys, and Glu from all organisms (except Mycoplasma) and organelles have a 2-thiouridine derivative (xm(5)s(2)U) as wobble nucleoside. These tRNAs read the A- and G-ending codons in the split codon boxes His/Gln, Asn/Lys, and Asp/Glu. In eukaryotic cytoplasmic tRNAs the conserved constituent (xm(5)-) in position 5 of uridine is 5-methoxycarbonylmethyl (mcm(5)). A protein (Tuc1p)...

Topics

Amino Acid Sequence
Cytoplasm
Molecular Sequence Data
Mutation
Nucleosides
RNA, Transfer, Amino Acyl
RNA, Transfer, Gln
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 17592039
DOI: 10.1261/rna.558707
PMCID: PMC1924908

Genes

ELP3

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