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Article

The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.

Nature genetics - 1 Jan 2001

Peterson S E, Stellwagen A E, Diede S J, Singer M S, Haimberger Z W, Johnson C O, Tzoneva M, Gottschling D E

Abstract excerpt

The telomerase enzyme lengthens telomeres, an activity essential for chromosome stability in most eukaryotes. The enzyme is composed of a specialized reverse transcriptase and a template RNA. In Saccharomyces cerevisiae, overexpression of TLC1, the telomerase RNA gene, disrupts telomeric structure. The result is both shortened telomere length and loss of a special chromatin structure that normally silences...

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Share to Antigens, Nuclear
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11138000
DOI: 10.1038/83778

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.PMID 11138000Read ↗

RNA recognition by the DNA end-binding Ku heterodimer.Semantic proximity Read ↗

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Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.Semantic proximity Read ↗

A new telomerase RNA element that is critical for telomere elongation.Semantic proximity Read ↗

Cell cycle-dependent transcription factors control the expression of yeast telomerase RNA.Semantic proximity Read ↗

Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction.Semantic proximity Read ↗

The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiaeSemantic proximity Read ↗

Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by rif proteins.Semantic proximity Read ↗

A 4-base pair core-enclosing helix in telomerase RNA is essential and binds to the TERT catalytic protein subunitSemantic proximity Read ↗

The interaction between the yeast telomerase RNA and the Est1 protein requires three structural elements.Semantic proximity Read ↗

A bulged stem tethers Est1p to telomerase RNA in budding yeast.Semantic proximity Read ↗

Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro.Semantic proximity Read ↗

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