Plasminogen activator inhibitor type 1 serum levels and 4G/5G gene polymorphism in morbidly obese Hispanic patients with non-alcoholic fatty liver disease.

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Plasminogen activator inhibitor type 1 serum levels and 4G/5G gene polymorphism in morbidly obese Hispanic patients with non-alcoholic fatty liver disease.

Annals of hepatology - 1 Jan 2000

Espino Alberto, Villagrán Andrea, Vollrath Valeska, Hanckes Paulina, Salas Roberto, Farah Andrea, Solís Nancy, Pizarro Margarita, Escalona Alex, Boza Camilo, Pérez Gustavo, Carrasco Gonzalo, Padilla Oslando, Miquel Juan Francisco, Nervi Flavio, Chavez-Tapia Norberto C, Arab Juan Pablo, Alvarez-Lobos Manuel, Arrese Marco, Riquelme Arnoldo

Abstract excerpt

BACKGROUND: The plasminogen activator inhibitor type-1 (PAI-1) has been implicated in the regulation of fibrinolysis and extracellular matrix components. The single base pair guanine insertion/deletion polymorphism (4G/5G) within the promoter region of the PAI-1 gene influences PAI-1 synthesis and may modulate hepatic fibrogenesis. AIM: To evaluate the influence of PAI-1 serum levels and 4G/5G polymorphism on the...

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PMID: 21911891

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