Plasminogen activator inhibitor-1 (PAI-1) gene polymorphism (-675 4G/5G) associated with obesity and vascular risk in children.

doi:10.1515/jpem.2006.19.5.741

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Article

Plasminogen activator inhibitor-1 (PAI-1) gene polymorphism (-675 4G/5G) associated with obesity and vascular risk in children.

Journal of pediatric endocrinology & metabolism : JPEM - 1 May 2006

Berberoğlu M, Evliyaoğlu O, Adiyaman P, Ocal G, Ulukol B, Simşek F, Siklar Z, Törel A, Ozel D, Akar N

Abstract excerpt

UNLABELLED: Atherothrombotic complications in insulin resistance are partly attributed to impaired fibrinolysis caused by increased PAI-1 plasma levels, and 4G/5G promotor polymorphism of the PAI-1 gene may modulate PAI-1 transcription. OBJECTIVE: To investigate PAI-1-675 4G/5G allele gene polymorphism and its relationship with obesity in children. CHILDREN AND METHOD: The study participants were 133 apparently...

Topics

Adult
Alleles
Blood Glucose
Body Mass Index
Child
Gene Frequency
Humans
Hyperinsulinism
Insulin
Metabolic Syndrome
Obesity
Odds Ratio
Plasminogen Activator Inhibitor 1
Polymorphism, Genetic

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Risk Factors

Treatment Outcome

Vascular Diseases

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Open in PubMed

Identifiers

PMID: 16789641
DOI: 10.1515/jpem.2006.19.5.741

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