Article
Role of the 4G/5G polymorphism of PaI-1 gene promoter on PaI-1 levels in obese patients: influence of fat distribution and insulin-resistance.
Thrombosis and haemostasis - 1 Nov 2001
Sartori M T, Vettor R, De Pergola G, De Mitrio V, Saggiorato G, Della Mea P, Patrassi G M, Lombardi A M, Fabris R, Girolami A
Abstract excerpt
As PAI-1, a cardiovascular risk factor linked to insulin-resistance, may be influenced by a 4G/5G gene polymorphism in disease states, we studied both PAI-1 plasma concentration (PAI-1:Ag) and 4G/5G polymorphism, and their relationship with anthropometric and endocrinemetabolic parameters in 93 obese patients and 79 lean normal subjects. In obese patients PAI-1:Ag levels were significantly increased, namely in...
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