Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduction of N-tropic mutant porcine endogenous retrovirus infectivity by human tripartite motif-containing 5-isoform alpha.

Transplantation proceedings - 1 Sept 2011

Lee J, Cho Y D, Heo Y K, Kwon Y, Kim D G, Choi B-S, Kim S S, Kim Y B

Abstract excerpt

In cases of retroviral infection, the host cell deploys antiviral proteins as a type of innate immunity. Tripartite motif-containing 5-isoform alpha (TRIM5α) is a potent antiviral protein. TRIM5α has been reported to restrict human immunodeficiency virus (HIV) 1 infection in rhesus monkey cells by targeting the incoming viral capsid at the postentry or preintegration stage of the viral life cycle. As a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Cell Line
Share to DNA Primers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endogenous Retroviruses

Share to Mutagenesis, Site-Directed

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Sequence Homology, Amino Acid

Share to Virulence

Source

Identifiers

PMID: 21911161
DOI: 10.1016/j.transproceed.2011.04.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduction of N-tropic mutant porcine endogenous retrovirus infectivity by human tripartite motif-containing 5-isoform alpha.PMID 21911161Read ↗

Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor FunctioningSemantic proximity Read ↗

Preclinical Assessment of Mutant Human TRIM5α as an Anti-HIV-1 Transgene.Semantic proximity Read ↗

Editing of the human TRIM5 gene to introduce mutations with the potential to inhibit HIV-1.Semantic proximity Read ↗

Editing of the TRIM5 gene decreases the permissiveness of human T lymphocytic cells to HIV-1Semantic proximity Read ↗

Editing of the Human TRIM5 Gene to Introduce Mutations with the Potential to Inhibit HIV-1Semantic proximity Read ↗

The role of tripartite motif family members in mediating susceptibility to HIV-1 infectionSemantic proximity Read ↗

Human Tripartite Motif 5α Domains Responsible for Retrovirus Restriction Activity and SpecificitySemantic proximity Read ↗

Interfering Residues Narrow the Spectrum of MLV Restriction by Human TRIM5αSemantic proximity Read ↗

A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5αSemantic proximity Read ↗

Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5αSemantic proximity Read ↗

TRIM5α variations influence transduction efficiency with lentiviral vectors in both human and rhesus CD34(+) cells in vitro and in vivo.Semantic proximity Read ↗

TRIM5 and the Regulation of HIV-1 InfectivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.