Article

A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α

2020-04-22

Abstract excerpt

<h4>ABSTRACT</h4> TRIM5α is a key cross-species barrier to retroviral infection, with certain TRIM5 alleles conferring increased risk of HIV-1 infection in humans. TRIM5α is best known as a species-specific restriction factor that directly inhibits the viral life cycle. Additionally, it is also a pattern-recognition receptor (PRR) that activates inflammatory signaling. How TRIM5α carries out its multi-faceted act...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cc104660-f7a5-5e4b-a326-91c16111fdcb
DOI: 10.1101/2020.04.21.053207

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5αDOI 10.1101/2020.04.21.053207Read

Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor FunctioningSemantic proximity Read

TRIM5α Degradation via Autophagy Is Not Required for Retroviral RestrictionSemantic proximity Read

A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteinsSemantic proximity Read

TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune SignalingSemantic proximity Read

TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal DegradationSemantic proximity Read

TRIM5 and the Regulation of HIV-1 InfectivitySemantic proximity Read

Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagySemantic proximity Read

TRIM Proteins and Their Roles in Antiviral Host DefensesSemantic proximity Read

TRIM proteins: New players in virus-induced autophagySemantic proximity Read

The role of tripartite motif family members in mediating susceptibility to HIV-1 infectionSemantic proximity Read

Canonical and Non-Canonical Autophagy in HIV-1 Replication CycleSemantic proximity Read

RanBP2 regulates the anti-retroviral activity of TRIM5α by SUMOylation at a predicted phosphorylated SUMOylation motifSemantic proximity Read