Article
[A joint study of mutation of the Ki-ras oncogene and overexpression of the Tp53 oncogene in colorectal cancer].
Gastroenterologie clinique et biologique - 1 Jan 1990
Laurent-Puig P, Delattre O, Olschwang S, Remvikos Y, Melot T, Salmon R J, Frelat G, Thomas G
Abstract excerpt
Twenty-five colorectal tumors (rectum 6, left colon 13, right colon 6) were studied with respect to the overexpression of p53 and the activation by point mutation of the Ki-ras oncogene. Single point mutations on codon 12 and codon 13 were analyzed after PCR amplivication, dotblotting and sequent...
Topics
- Adenocarcinoma
- Codon
- Colorectal Neoplasms
- Female
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Humans
- Male
- Mutation
- Oncogenes
- Polymerase Chain Reaction
