Article
White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis.
Cell metabolism - 7 Sept 2011
Cao Lei, Choi Eugene Y, Liu Xianglan, Martin Adam, Wang Chuansong, Xu Xiaohua, During Matthew J
Abstract excerpt
Living in an enriched environment with complex physical and social stimulation leads to improved cognitive and metabolic health. In white fat, enrichment induced the upregulation of the brown fat cell fate determining gene Prdm16, brown fat-specific markers, and genes involved in thermogenesis and β-adrenergic signaling. Moreover, pockets of cells with prototypical brown fat morphology and high UCP1 levels were...
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