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Article

A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents.

Journal of cardiovascular electrophysiology - 1 Apr 2007

Shuraih Mossaab, Ai Tomohiko, Vatta Matteo, Sohma Yoshiro, Merkle Eileen M, Taylor Erica, Li Zhaohui, Xi Yutao, Razavi Mehdi, Towbin Jeffrey A, Cheng Jie

Abstract excerpt

BACKGROUND: The potential pathophysiological role of common SCN5A polymorphisms in cardiac arrhythmias has been increasingly recognized. However, little is known about the impact of those polymorphisms on the pharmocological response of hNav1.5 to various antiarrhythmic agents. METHODS AND RESULT...

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Source

Identifiers

PMID: 17331104
DOI: 10.1111/j.1540-8167.2007.00777.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17331104-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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