Influence of acetylator status on the haemodynamic effects and pharmacokinetics of cadralazine in healthy subjects.

doi:10.1111/j.1365-2125.1990.tb03672.x

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Article

Influence of acetylator status on the haemodynamic effects and pharmacokinetics of cadralazine in healthy subjects.

British journal of clinical pharmacology - 1 May 1990

Brunel P, Lecaillon J B, Guyene T T, Imhof P, Ménard J

Abstract excerpt

1. Cadralazine is a new antihypertensive agent which causes peripheral vasodilation, probably mediated by a hydrazinopyridazine metabolite. 2. The possible influence of acetylator status on the pharmacokinetics and haemodynamics of the drug was studied in six fast and six slow acetylators over a...

Topics

Acetylation
Adult
Antihypertensive Agents
Blood Pressure
Forearm
Heart Rate
Hemodynamics
Humans
Male
Middle Aged
Phenotype
Pyridazines
Regional Blood Flow
Renin
Stroke Volume
Vasodilation

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