Article
Plasma concentration and acetylator phenotype determine response to oral hydralazine.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2000
Shepherd A M, McNay J L, Ludden T M, Lin M S, Musgrave G E
Abstract excerpt
The vasodepressor response to single and multiple oral doses of hydralazine, 1 mg/kg, was studied in hypertensive patients. The concentration of hydralazine in plasma was measured both by a newly developed specific and a nonspecific assay similar to those used in previous studies. Acetylator phen...
Topics
- Acetylation
- Administration, Oral
- Aged
- Blood Pressure
- Dose-Response Relationship, Drug
- Humans
- Hydralazine
- Hypertension
- Male
- Middle Aged
- Phenotype
- Sulfamethazine