Article
The influence of pyruvic acid on the pharmacokinetics of sulphadiazine in rabbits.
Biopharmaceutics & drug disposition - 1 Apr 1995
Hsu K Y, Song D J, Ho Y
Abstract excerpt
During the past few years, acetylation polymorphism has been shown to be a proven, established fact, and N-acetyltransferase, an enzyme that transfers an acetyl group to the substrate, has been recognized as the main factor in acetylation polymorphism. In a recent study, a significant difference between the acetylation phenotype and plasma pyruvic acid (PA) concentration in rabbits was found. In this report, the...
Topics
- Acetylation
- Animals
- Drug Interactions
- Infusions, Intravenous
- Male
- Phenotype
- Pyruvates
- Pyruvic Acid
- Rabbits
- Sulfadiazine