Article
Phenotyping mouse chromosome substitution strains reveal multiple QTLs for febrile seizure susceptibility.
Genes, brain, and behavior - 1 Mar 2009
Hessel E V S, van Gassen K L I, Wolterink-Donselaar I G, Stienen P J, Fernandes C, Brakkee J H, Kas M J H, de Graan P N E
Abstract excerpt
Febrile seizures (FS) are the most common seizure type in children and recurrent FS are a risk factor for developing temporal lobe epilepsy. Although the mechanisms underlying FS are largely unknown, recent family, twin and animal studies indicate that genetics are important in FS susceptibility. Here, a forward genetic strategy was used employing mouse chromosome substitution strains (CSS) to identify novel FS...
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