Article

Meta-analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

2025-08-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Despite decades of development in anti-seizure medications, approximately 30% of individuals remain refractory to all treatments, and none of the existing therapies are disease-modifying. Identifying targets outside the current preclinical paradigm is critically important. This study aimed to characterize the landscape of current epilepsy treatments at the level of gene inter...

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Literature Corpus work: a3a405a2-77c3-5d3e-8a47-8d35f9358e8c
DOI: 10.1101/2025.08.15.669922

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