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Article

Disruptive TP53 mutation is associated with aggressive disease characteristics in an orthotopic murine model of oral tongue cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2011

Sano Daisuke, Xie Tong-Xin, Ow Thomas J, Zhao Mei, Pickering Curtis R, Zhou Ge, Sandulache Vlad C, Wheeler David A, Gibbs Richard A, Caulin Carlos, Myers Jeffrey N

Abstract excerpt

PURPOSE: To characterize tumor growth and metastatic potential in head and neck squamous cell carcinoma (HNSCC) cell lines in an orthotopic murine model of oral tongue cancer and to correlate TP53 mutation status with these findings. EXPERIMENTAL DESIGN: Cells from each of 48 HNSCC cell lines were orthotopically injected into the oral tongues of nude mice. Tumor volume, cervical lymph node metastasis, and mouse...

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Share to Carcinoma, Squamous Cell
Share to Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Mice, Nude

Share to Squamous Cell Carcinoma of Head and Neck

Share to Tongue Neoplasms

Share to Transplantation, Heterologous

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 21903770
DOI: 10.1158/1078-0432.CCR-11-0046
PMCID: PMC3207013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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