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Article

TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2012

Skinner Heath D, Sandulache Vlad C, Ow Thomas J, Meyn Raymond E, Yordy John S, Beadle Beth M, Fitzgerald Alison L, Giri Uma, Ang K Kian, Myers Jeffrey N

Abstract excerpt

PURPOSE: Mortality of patients with head and neck squamous cell carcinoma (HNSCC) is primarily driven by tumor cell radioresistance leading to locoregional recurrence (LRR). In this study, we use a classification of TP53 mutation (disruptive vs. nondisruptive) and examine impact on clinical outcomes and radiation sensitivity. EXPERIMENTAL DESIGN: Seventy-four patients with HNSCC treated with surgery and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22090360
DOI: 10.1158/1078-0432.CCR-11-2260
PMCID: PMC3251726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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