Article
Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2017
Tanaka Noriaki, Patel Ameeta A, Tang Lin, Silver Natalie L, Lindemann Antje, Takahashi Hideaki, Jaksik Roman, Rao Xiayu, Kalu Nene N, Chen Tseng-Cheng, Wang Jiping, Frederick Mitchell J, Johnson Faye, Gleber-Netto Frederico O, Fu Siqing, Kimmel Marek, Wang Jing, Hittelman Walter N, Pickering Curtis R, Myers Jeffrey N, Osman Abdullah A
Abstract excerpt
Purpose: The cure rate for patients with advanced head and neck squamous cell carcinoma (HNSCC) remains poor due to resistance to standard therapy primarily consisting of chemoradiation. As mutation of TP53 in HNSCC occurs in 60% to 80% of non-HPV-associated cases and is in turn associated with resistance to these treatments, more effective therapies are needed. In this study, we evaluated the efficacy of a...
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