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Article

Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography.

Human genetics - 1 Jan 2014

Koran Mary Ellen I, Hohman Timothy J, Thornton-Wells Tricia A

Abstract excerpt

Late-onset Alzheimer's disease (LOAD) is known to have a complex, oligogenic etiology, with considerable genetic heterogeneity. We investigated the influence of genetic interactions between genes in the Alzheimer's disease (AD) pathway on amyloid-beta (Aβ) deposition as measured by PiB or AV-45 ligand positron emission tomography (PET) to aid in understanding LOAD's genetic etiology. Subsets of the Alzheimer's...

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Share to Alzheimer Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoprotein E4

Share to Calcium Channels, L-Type

Share to Epistasis, Genetic

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Share to Ryanodine Receptor Calcium Release Channel

Source

Open in PubMed Open full text

Identifiers

PMID: 24026422
DOI: 10.1007/s00439-013-1354-8
PMCID: PMC4045094

Genes

RYR3

Provenance

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