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Article

Patterns of gene expression in Drosophila InsP3 receptor mutant larvae reveal a role for InsP3 signaling in carbohydrate and energy metabolism.

PloS one - 1 Jan 2011

Kumar Satish, Dey Debleena, Hasan Gaiti

Abstract excerpt

BACKGROUND: The Inositol 1,4,5-trisphosphate receptor (InsP(3)R) is an InsP(3) gated intracellular Ca(2+)-release channel. Characterization of Drosophila mutants for the InsP(3)R has demonstrated that InsP(3)-mediated Ca(2+) release is required in Drosophila larvae for growth and viability. METHODOLOGY/PRINCIPAL FINDINGS: To understand the molecular basis of these growth defects a genome wide microarray analysis...

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Identifiers

PMID: 21901161
DOI: 10.1371/journal.pone.0024105
PMCID: PMC3162032

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