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Article

Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia.

Disease models & mechanisms - 1 May 2013

Subramanian Manivannan, Metya Suman Kumar, Sadaf Sufia, Kumar Satish, Schwudke Dominik, Hasan Gaiti

Abstract excerpt

Obesity is a complex metabolic disorder that often manifests with a strong genetic component in humans. However, the genetic basis for obesity and the accompanying metabolic syndrome is poorly defined. At a metabolic level, obesity arises from an imbalance between the nutritional intake and energy utilization of an organism. Mechanisms that sense the metabolic state of the individual and convey this information...

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Identifiers

PMID: 23471909
DOI: 10.1242/dmm.010017
PMCID: PMC3634656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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