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Article

Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8⁺ T cells in early viral evolution.

Journal of virology - 1 Nov 2011

Callendret Benoît, Bukh Jens, Eccleston Heather B, Heksch Ryan, Hasselschwert Dana L, Purcell Robert H, Hughes Austin L, Walker Christopher M

Abstract excerpt

The RNA genome of the hepatitis C virus (HCV) diversifies rapidly during the acute phase of infection, but the selective forces that drive this process remain poorly defined. Here we examined whether Darwinian selection pressure imposed by CD8(+) T cells is a dominant force driving early amino acid replacement in HCV viral populations. This question was addressed in two chimpanzees followed for 8 to 10 years...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21900166
DOI: 10.1128/JVI.02654-10
PMCID: PMC3209267

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