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Article

Evolutionary dynamics of hepatitis C virus envelope genes during chronic infection.

The Journal of general virology - 1 Jul 2005

Brown Richard J P, Juttla Vicky S, Tarr Alexander W, Finnis Rebecca, Irving William L, Hemsley Shelley, Flower Darren R, Borrow Persephone, Ball Jonathan K

Abstract excerpt

Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are important targets for the host immune response. The genes encoding these proteins exhibit a high degree of variability that gives rise to differing phenotypic traits, including alterations in receptor-binding affinity and immune recognition and escape. In order to elucidate patterns of adaptive evolution during chronic infection, a panel of full-length...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15958671
DOI: 10.1099/vir.0.80957-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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