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Article

Evolution of a cell culture-derived genotype 1a hepatitis C virus (H77S.2) during persistent infection with chronic hepatitis in a chimpanzee.

Journal of virology - 1 Apr 2014

Yi MinKyung, Hu Fengyu, Joyce Michael, Saxena Vikas, Welsch Christoph, Chavez Deborah, Guerra Bernadette, Yamane Daisuke, Veselenak Ronald, Pyles Rick, Walker Christopher M, Tyrrell Lorne, Bourne Nigel, Lanford Robert E, Lemon Stanley M

Abstract excerpt

UNLABELLED: Persistent infection is a key feature of hepatitis C virus (HCV). However, chimpanzee infections with cell culture-derived viruses (JFH1 or related chimeric viruses that replicate efficiently in cell culture) have been limited to acute-transient infections with no pathogenicity. Here, we report persistent infection with chronic hepatitis in a chimpanzee challenged with cell culture-derived genotype 1a...

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Identifiers

PMID: 24429362
DOI: 10.1128/JVI.03540-13
PMCID: PMC3993530

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