Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia.

doi:10.1002/ajmg.b.31233

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Article

Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2011

Deng Xiangdong, Takaki Hiromi, Wang Lixiang, Kuroki Tosihide, Nakahara Tatsuo, Hashimoto Kijiro, Ninomiya Hideaki, Arinami Tadao, Inada Toshiya, Ujike Hiroshi, Itokawa Masanari, Tochigi Mamoru, Watanabe Yuichiro, Someya Toshiyuki, Kunugi Hiroshi, Iwata Nakao, Ozaki Norio, Shibata Hiroki, Fukumaki Yasuyuki

Abstract excerpt

As schizophrenia-like symptoms are produced by administration of phencyclidine (PCP), a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, PCP-responsive genes could be involved in the pathophysiology of schizophrenia. We injected PCP to Wistar rats and isolated five different parts of the brain in 1 and 4 hr after the injection. We analyzed the gene expression induced by the PCP treatment of...

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Identifiers

PMID: 21898905
DOI: 10.1002/ajmg.b.31233

Genes

PLAT
BTG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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