Article
Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia.
Molecular psychiatry - 1 May 2001
Mirnics K, Middleton F A, Stanwood G D, Lewis D A, Levitt P
Abstract excerpt
Complex defects in neuronal signaling may underlie the dysfunctions that characterize schizophrenia. Using cDNA microarrays, we discovered that the transcript encoding regulator of G-protein signaling 4 (RGS4) was the most consistently and significantly decreased in the prefrontal cortex of all schizophrenic subjects examined. The expression levels of ten other RGS family members represented on the microarrays...
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