Article
Genetic association between 5'-upstream single-nucleotide polymorphisms of PDGFRB and schizophrenia in a Korean population.
Schizophrenia research - 1 Aug 2008
Kim Hak-Jae, Kim Min-Ho, Choe Bong-Keun, Kim Jong Woo, Park Jin Kyung, Cho Ah-Rang, Bae Hyunsu, Shin Dong-Hun, Yim Sung Vin, Kwack KyuBum, Kwon Yunhee Kim, Chung Joo-Ho
Abstract excerpt
PDGFRB is located on chromosome 5q31-q32, a chromosomal region identified by linkage analyses to contain a susceptibility gene for schizophrenia (SCZ). Recent research has focused on the role of the N-methyl-d-aspartate (NMDA) receptor in the pathogenesis of SCZ. D4 dopamine receptor-mediated transactivation of the gene encoding platelet-derived growth factor receptor beta (PDGFRB) has immediate effects on...
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