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Article

Immunoglobulin M levels inversely correlate with CD40 ligand promoter methylation in patients with primary biliary cirrhosis.

Hepatology (Baltimore, Md.) - 1 Jan 2012

Lleo Ana, Liao Jieyue, Invernizzi Pietro, Zhao Ming, Bernuzzi Francesca, Ma Le, Lanzi Gaetana, Ansari Aftab A, Coppel Ross L, Zhang Peng, Li Yijun, Zhou Zhiguang, Lu Qianjin, Gershwin M Eric

Abstract excerpt

UNLABELLED: The cross-talk of cluster of differentiation (CD)40/CD40 ligand (CD40L) plays a key role in CD4(+) T-cell priming, B-cell terminal maturation, and immunoglobulin (Ig) class-switch recombination. Genetic defects in the CD40L lead to a disorder characterized by elevated concentrations of serum IgM and immunodeficiency. Patients with primary biliary cirrhosis (PBC) characteristically show circulating...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21898485
DOI: 10.1002/hep.24630
PMCID: PMC3245335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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