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Article

CD40 ligand deficiency: treatment strategies and novel therapeutic perspectives

25 Jan 2019

Abstract excerpt

INTRODUCTION: CD40 ligand (CD40L) deficiency or X-linked Hyper-IgM syndrome is a severe primary immunodeficiency caused by mutations in the CD40L gene. Despite currently available treatments, CD40L-deficient patients remain susceptible to life-threatening infections and have poor long term survival. Areas covered: Here, we discuss clinical and immunological characteristics of CD40L deficiency as well as current...

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PMID: 30681380
DOI: 10.1080/1744666x.2019.1573674

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