Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes.

Immunologic research - 1 Jan 2001

Bhushan A, Covey L R

Abstract excerpt

Hyper-IgM (HIM) syndrome is a rare immunodeficiency characterized by low or absent IgG, IgA, and IgE with normal or elevated levels of IgM. This disorder can be acquired or familial with either X-linked or autosomal patterns of inheritance. The X-linked form of the disease is a consequence of mutations in the CD40 ligand (CD40L) gene that encodes a protein expressed primarily on activated CD4+ T cells. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to CD40 Antigens
Share to CD40 Ligand

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypergammaglobulinemia

Share to Immunoglobulin Class Switching

Share to Immunoglobulin M

Share to Immunologic Deficiency Syndromes

Share to X Chromosome

Source

Identifiers

PMID: 11817328
DOI: 10.1385/IR:24:3:311

Genes

CD40
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes.PMID 11817328Read ↗

Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM.Semantic proximity Read ↗

CD40lbase: a database of CD40L gene mutations causing X-linked hyper-IgM syndrome.Semantic proximity Read ↗

X-linked hyper IgM syndrome: clinical, immunological and molecular features in patients from India.Semantic proximity Read ↗

Clinical and molecular characterization of X-linked hyper-IgM syndrome patients in China.Semantic proximity Read ↗

Hyper IgM syndrome: the other side of the coin.Semantic proximity Read ↗

A novel mutation in the CD40 ligand gene in a Chinese boy with X-linked hyper-IgM syndrome.Semantic proximity Read ↗

Correction of neutropenia and hypogammaglobulinemia in X-linked hyper-IgM syndrome by allogeneic bone marrow transplantation.Semantic proximity Read ↗

Clinical features and genetic analysis of 20 Chinese patients with X-linked hyper-IgM syndrome.Semantic proximity Read ↗

Type І hyper IgM syndrome with novel mutation from India.Semantic proximity Read ↗

CD40 ligand mutants responsible for X-linked hyper-IgM syndrome associate with wild type CD40 ligand.Semantic proximity Read ↗

Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome.Semantic proximity Read ↗

X-linked hyper-immunoglobulin M syndrome harboring a novel CD40-ligand gene mutation: a case report.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.