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Article

Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis.

Journal of autoimmunity - 1 Jun 2005

Kikuchi Kentaro, Lian Zhe-Xiong, Kimura Yasuhiko, Selmi Carlo, Yang Guo-Xiang, Gordon Stuart C, Invernizzi Pietro, Podda Mauro, Coppel Ross L, Ansari Aftab A, Ikehara Susumu, Miyakawa Hiroshi, Gershwin M Eric

Abstract excerpt

The serum hallmark of primary biliary cirrhosis (PBC) is the presence of anti-mitochondrial antibodies (AMA), found in 95% of patients. However, nearly every patient with PBC, including those who are AMA-negative, has an elevation in serum IgM. This hyper-IgM is neither representative of other Ig isoforms, nor is due to the levels of AMA. In fact, we have recently reported that the hyper-IgM is an innate immune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukocytes, Mononuclear

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Source

Identifiers

PMID: 15878652
DOI: 10.1016/j.jaut.2005.03.002

Genes

TLR9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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