Article
Analysis of CD40 ligand gene mutations in patients with primary biliary cirrhosis.
Scandinavian journal of clinical and laboratory investigation - 1 Aug 1998
Higuchi M, Horiuchi T, Kojima T, Nishizaka H, Ishibashi H, Hayashi K, Niho Y, Nagasawa K
Abstract excerpt
An elevated immunoglobulin (Ig)M concentration in serum is a common and distinctive feature of primary biliary cirrhosis (PBC). Little is known, however, about the mechanism of hyper-IgM in PBC. CD40 ligand (CD40L) has a crucial role in immunoglobulin class switching in B cells. Mutations in the...
Topics
- Aged
- Base Sequence
- CD40 Ligand
- DNA Primers
- DNA, Complementary
- Humans
- Liver Cirrhosis, Biliary
- Membrane Glycoproteins
- Middle Aged
- Mutation
- Polymorphism, Single-Stranded Conformational
- RNA, Messenger
- Reverse Transcriptase Polymerase Chain Reaction