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Article

A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product.

Nature - 14 Mar 1991

Huang S, Lee W H, Lee E Y

Abstract excerpt

Tumour-suppressor genes, such as the human retinoblastoma susceptibility gene (Rb), are widely recognized as being vital in the control of cell growth and tumour formation. This role is indicated, in part, by the suppression of tumorigenicity of human tumour cells after retrovirus-mediated Rb replacement. How Rb acts to bring about this suppression is not clear but one clue is that the Rb protein forms complexes...

Topics

Amino Acid Sequence
Antigens, Polyomavirus Transforming
Binding, Competitive
Blotting, Western
Cell Line
DNA-Binding Proteins
Electrophoresis, Polyacrylamide Gel
Genes, Retinoblastoma
HeLa Cells
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Proteins

Nuclear Proteins

Plasmids

Retinoblastoma Protein

Source

Identifiers

PMID: 2005966
DOI: 10.1038/350160a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2005966-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product.PMID 2005966Read ↗

Dual Retinoblastoma-binding Proteins with Properties Related to a Negative Regulator of Ras in YeastSemantic proximity Read ↗

Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.Semantic proximity Read ↗

PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb.Semantic proximity Read ↗

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.Semantic proximity Read ↗

p53 mutants with changes in conserved region II: three classes with differing antibody reactivity, SV40 T antigen binding and ability to inhibit transformation of rat cells.Semantic proximity Read ↗

Identification of simian virus 40 T-antigen residues important for specific and nonspecific binding to DNA and for helicase activity.Semantic proximity Read ↗

Converting the JCV T antigen Rb binding domain to that of SV40 does not alter JCV's limited transforming activity but does eliminate viral viability.Semantic proximity Read ↗

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