Article
Human retinoblastoma susceptibility gene.
Genetic engineering - 1 Jan 1990
Lai C C, Lee W H
Abstract excerpt
It is clear that the RB-deficient tumor cells lost their tumorigenicity in nude mice after regaining the RB gene expression. However, the mechanism of tumor suppression by the RB gene is still unknown. More studies on the biological activities of RB protein, pp110RB, are necessary to answer this question. Recent studies have shown that several oncogenic viral proteins, such as SV40 large T antigen (47) and...
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