Psychological distress in fibromyalgia patients: a role for catechol-O-methyl-transferase Val158met polymorphism.

doi:10.1037/a0025223

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Article

Psychological distress in fibromyalgia patients: a role for catechol-O-methyl-transferase Val158met polymorphism.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association - 1 Mar 2012

Desmeules Jules, Piguet Valérie, Besson Marie, Chabert Jocelyne, Rapiti Elisabetta, Rebsamen Michela, Rossier Michel F, Curtin François, Dayer Pierre, Cedraschi Christine

Abstract excerpt

OBJECTIVE: Fibromyalgia (FM) has been related to biochemical alterations, central pain sensitization and psychological distress. Among genetic and environmental hypotheses, a role was suggested for catechol-O-methyl-transferase (COMT), a modulator in the metabolism of monoaminergic neurotransmitters. METHOD: This study compared the COMT Val158Met enzyme polymorphism (rs4680) of 198 FM patients to 99 pain-free...

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PMID: 21895373
DOI: 10.1037/a0025223

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COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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